Preheat oven to 375°F and line a baking sheet with foil.
Mix breadcrumbs with milk in bowl and let soak 5 minutes.
Add beef, egg, ketchup, Dijon, and Worcestershire sauce to the bowl.
Add dried onion, garlic powder, onion powder, and chili powder.
Mix with hands just until combined (don't overmix!).
Divide into 4 equal portions.
Shape into mini loaves on baking sheet.
Press a small well on top of each loaf.
Mix 1/3 cup ketchup with brown sugar and a splash of Worcestershire for glaze.
Spoon glaze over each mini loaf.
Bake 25-30 minutes until 160°F internal temperature.
Rest 5 minutes before serving.